Clinical manifestation of severe hyperammonaemia in patients with multiple myeloma

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Mandibular Swelling as the First Manifestation of Multiple Myeloma

Multiple myeloma is a monoclonal malignant proliferation of plasma cells. The disease is more frequent in men, and the average age of patients at the time of diagnosis of the disease is about 60 years. Solitary myeloma may be the first manifestation of the disseminated form of multiple myeloma, which is characterized by multiple skeletal lesions, general metabolic alterations, impairment of ren...

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Introduction: Multiple myeloma (MM) is typically presented with abundant monoclonal secretion of one type of immunoglobulin. The other classes of immunoglobulins, which are uninvolved and not secreted by malignant plasma cells, could be decreased. A number of previous studies reported the effect of suppression of uninvolved immunoglobulins on the outcome of patients with myeloma. However, its e...

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ژورنال

عنوان ژورنال: Annals of Oncology

سال: 1997

ISSN: 0923-7534

DOI: 10.1023/a:1008236018377